YOUR PARTNER FOR

FOOD, BEVERAGE,

NUTRITION & HEALTH

IPRONA 水果公司

水果加工与选择性浓缩的B2B 市场领导者

我们是浆果、柑橘和热带水果浓缩汁的领先供应商。
我们也供应草本植物和种子冲泡茶;从水果中提取的天然食用色素和红色浆果的营养标准化提取物。最近,我们的复合饮料业务部门成功地为客户提供了专属预混合解决方案。

IPRONA 是一家拥有 35 年历史的全球供应商。  我们拥有新型食品和饮料生产技术,并且始终提供质量保证,因而得以扩大业务和实现销售增长。

LATEST NEWS

NEW PATENT FOR ElderCraft®

Black Elderberry extract inhibits the replication of SARS-CoV2 in vitro

A new study of the researchers at the University Erlangen has shown ElderCraft® Black Elderberry Extract has a strong antiviral effect against SARS-CoV-2. Encouraged by the findings, IPRONA has filed to internationally patent ElderCraft® for use in the prevention and treatment of COVID-19.

更多

The University of Erlangen, Institute for Virology under the direction of Prof. Schubert studied the effect of ElderCraft®, an extract made by IPRONA from Sambucus nigra, L. black elderberries (variety Haschberg) on the SARS-CoV-2 coronavirus that causes COVID-19. The tests found the extract inhibits the replication of the wildtype virus, as well as the variants of concern Alpha and Beta, at very low concentrations.

Ongoing, further studies will evaluate the efficacy versus other variants of concern and seek to identify the Mode of Action by using time of application studies. Interestingly, the proprietary production process IPT (IPRONA Polyphenol Technology) used to make ElderCraft® seems to capture the inhibitory properties more efficiently than standard concentration techniques.

IPT is an entirely mechanical, solvent-free separation and ultra-filtration process that IPRONA uses to extract an active blend of natural fruit anthocyanins, polysaccharides and berry micronutrients from elderberries grown in southeast Austria by a cooperative of 250 farmers.

While the current research is still ongoing, the use of ElderCraft® for the prevention and treatment of  COVID-19 has been filed as an international patent application. The study results will be published in international journals over the course of the year, adding to the large volume of evidence of the positive effects of elderberry.

“It is fascinating to see that IPRONA`s elderberry extract ElderCraft® is able to inhibit the replication of SarsCov viruses even at very low concentrations. It has been known for a while that black elderberry is active against common influenza viruses, but this is the first time that an activity against the coronavirus SARS-CoV-2 and its variants of concern has been found. This opens the door for us and our partners to develop innovative Nutraceuticals as well as therapeutic products for the prevention and treatment of COVID-19” Stephan Plattner, Scientific Director of IPRONA, said.

The scientific studies build on centuries of use of black elderberry (Sambucus nigra L.) to treat flu and flu-like symptoms. In recent years, several human studies have confirmed the efficacy of black elderberry by showing a significant reduction in the duration and intensity of symptoms during influenza infections (1,2). 
The most recent human clinical study showed that ElderCraft® is able to significantly reduce the duration and intensity of influenza infections in long-haul flight passengers (3). In vitro studies indicate direct inhibition of viral replication through the blockage of viral receptors and the inhibition of key enzymes involved in viral replication (4). Other in vitro studies show the immune system seems to be positively influenced by components such as the polysaccharides present in the fruit of black elderberry (5).

Interest in those effects has increased during the COVID-19 pandemic. Even though infection with SARS-CoV-2 induces mild flu-like symptoms in the majority of those affected, some patients develop a severe form of the disease, including a progressive pneumonia due to an overreacting immune system. Therapeutic options for patients with moderate-to-severe COVID-19 remain limited and escape variants represent an additional threat. Accordingly, the development of novel anti-viral treatment options is eagerly awaited.


REFERENCES
1.     Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res. 2004;32(2):132-140. doi:10.1177/147323000403200205
2.     Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of Several Strains of Influenza Virus in Vitro and Reduction of Symptoms by an Elderberry Extract (Sambucus nigra L.) during an Outbreak of Influenza B Panama. J Altern Complement Med. 1995;1(4):361-369. doi:10.1089/acm.1995.1.361
3.     Tiralongo E, Wee SS, Lea RA. Elderberry supplementation reduces cold duration and symptoms in air-travellers: A randomized, double-blind placebo-controlled clinical trial. Nutrients. 2016;8(4). doi:10.3390/nu8040182
4.     Swaminathan K, Müller P, Downard KM. Substituent effects on the binding of natural product anthocyanidin inhibitors to influenza neuraminidase with mass spectrometry. Anal Chim Acta. 2014;828:61-69. doi:10.1016/j.aca.2014.04.021
5.     Kinoshita E, Hayashi K, Katayama H, Hayashi T, Obata A. Anti-influenza virus effects of elderberry juice and its fractions. Biosci Biotechnol Biochem. 2012;76(9):1633-1638. doi:10.1271/bbb.120112

If you want to learn more about ElderCraft®, don’t hesitate to contact us.

成立于 1981

位于意大利南蒂罗尔省拉纳市

遍及全球

成功遍及 60 多个国家和地区

研发

针对客户用途的专属产品

引领新趋势

采用先进技术实现多酚物质选择性富集,不使用高温或化学成分

IPRONA 业务部门

食品和飲料行業的配料

 

更多

產品開發 飲料行業

 

更多

促進健康的成分

 

更多

lg md sm xs